INTRODUCTION
Recent studies revealed the importance of gut microbiota in body health conditions.1 Understanding the gut microbiome started a new field of study that emphasizes the potential biochemical mechanisms of the healthy gut to local and distant organ diseases2 and study how the gut affects the skin is a new area of research.1 The gut and skin are both complex immune and neuroendocrine organs with a specific community of microbes that regulates the atmosphere of that part,3 and they have some effects on each other, especially the microbiome and its metabolites.1 A modification in the gut microbiota (dysbiosis) is related to type 2 diabetes, obesity, atopy, and cardiovascular disease.
Moreover, it has been shown that there is a possible relationship in the role of dysbiosis in the pathogenesis of skin conditions, including psoriasis, rosacea, and acne; however, we still need to do more clinical trials to have a better understanding of these disorders.4 Also, some gastrointestinal disorders accompany with dermatological skin abnormality. For instance, Celiac disease links to skin manifestations, such as erythema and oral lesions,5 and compared with healthy people, those who have Crohn’s disease present more possibility of having psoriasis.6
The positive effects of gut bacteria on skin health and appearance are determined in previous animal and human studies.1,4 As far as we know, no previous research has investigated the effect of probiotics supplementation in patients with psoriasis.
Psoriasis has long been observed as an immune-mediated chronic inflammatory disease with impairment in psychologic and emotional daily physical functioning and decreased quality of life (QOL).7 Regardless of the extensive use of several drugs,
Moreover, it has been shown that there is a possible relationship in the role of dysbiosis in the pathogenesis of skin conditions, including psoriasis, rosacea, and acne; however, we still need to do more clinical trials to have a better understanding of these disorders.4 Also, some gastrointestinal disorders accompany with dermatological skin abnormality. For instance, Celiac disease links to skin manifestations, such as erythema and oral lesions,5 and compared with healthy people, those who have Crohn’s disease present more possibility of having psoriasis.6
The positive effects of gut bacteria on skin health and appearance are determined in previous animal and human studies.1,4 As far as we know, no previous research has investigated the effect of probiotics supplementation in patients with psoriasis.
Psoriasis has long been observed as an immune-mediated chronic inflammatory disease with impairment in psychologic and emotional daily physical functioning and decreased quality of life (QOL).7 Regardless of the extensive use of several drugs,
