Dissolving Collagen Fillers: Enzymatic Degradation of Some Problematic Filler Circumstances May Now Include Collagens
December 2009 | Volume 8 | Issue 12 | 1140 | Copyright © December 2009
William D. Tutrone MD and Joel L. Cohen MD
Abstract
The market for non-permanent fillers has grown dramatically over the past years. Even though hyaluronic acid fillers and collagen are
forgiving, complications, albeit rare, still occur. Up to now, a necessary element of any dermatologic surgeons’ office is a hyaluronidase
in case one of these complications should occur. However, these agents will only work on hyaluronic acid fillers leaving any
problem with collagen products to be resolved by other means. Later this year the first collagenase could be approved for usage in
specific medical conditions; at that time it will, perhaps, complement its hyaluronidase counterpart. 
