Development of Hodgkin’s Lymphoma Under Bexarotene Treatment for Sézary Syndrome and Review of the Literature
August 2010 | Volume 9 | Issue 8 | 1014 | Copyright © August 2010
Hatice Sanli MD, Bengu Nisa Akay MD, Muhit Ozcan MD
Abstract
There are several reports of patients who developed extracutaneous lymphoma after they started bexarotene treatment. The authors
report a case in which the initiation of bexarotene therapy for Sézary syndrome was temporally associated with the development
of Hodgkin’s lymphoma despite improvement in cutaneous signs and symptoms. It is possible that bexarotene may contribute to
the development of extracutaneous lymphoma. Although bexarotene therapy may relieve symptoms and signs of cutaneous T-cell
lymphoma, careful examination of the lymph nodes during treatment is recommended. 
