Issue Archive
October 2010 | Volume 9 | Issue 10
Original Articles
Efficacy of Oral Metronidazole in Treatment ofCutaneous and Mucosal Lichen Planus
Introduction: Response to different antimicrobial agents supports the infection hypothesis for lichen planus (LP). There are individual case reports describing the improvement of LP with oral metroni...
Read MoreClinical Trial Review
Clinical Trial Review is a JDD department designed to provide physicians with information on drugs undergoing clinical testing. It is our goal to inform the reader of the status of select drug trials...
Read MoreThe Detection of Steroid Sulfatase Gene Deletion(STS) in Egyptian Males With X-linked Ichthyosis
Background: Ichthyosis is a disorder of keratinization characterized by diffuse uniform and persistent scales resulting from abnormal epidermal differentiation or metabolism. The identification of st...
Read MoreNews, Views & Reviews
News, Views and Reviews provides focused updates, topic reviews and editorials concerning the latest developments in dermatologic therapy....
Read MoreRetapamulin: An Antibacterial With a Novel Mode of Action in an Age of Emerging Resistance to Staphylococcus aureus
Staphylococcus aureus (S. aureus) is the leading cause of nosocomial infections and responsible for more than 11 million skin and soft tissue infections annually. Impetigo is a common skin infection ...
Read MorePipeline Previews
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatological community. This department may include additional information from ...
Read MoreIsotretinoin-induced Effects of Mast Cells on Wound Healing
Wound healing is a complex process, and the role of retinoids in wounds is confusing and controversial. In this study, the authors aimed to evaluate the role of oral isotretinoin on mast cells, colla...
Read MoreTreatment of Morphea or Localized Scleroderma: Review of the Literature
Scleroderma is a disease that affects the microvasculature and the connective tissue. These alterations produce fibrosis and blood vessel occlusion. Its cause is still unknown, although the exaggerat...
Read MoreVehicle or Placebo? Investigators Use Incorrect Terminology in Randomized Controlled Trials Half of the Time: A Systematic Review of Randomized Controlled Trials Published in Three Major Dermatology Journals
Background: A topical comparison in a randomized controlled trial (RCT) should correctly be termed a vehicle rather than a placebo as the vehicle in a dermatologic drug product enhances delivery and ...
Read MoreCutaneous Reactions to Epidermal Growth FactorReceptor Inhibitors
Cutaneous toxicities are the most common adverse effects of antineoplastic therapy with epidermal growth factor receptor (EGFR) inhibitors. Skin reactions to this class of agents usually present as p...
Read MoreAntibacterial Effects of a Chitosan-containing Spray: Results of a Pilot Study
Chitosan is a deacetylated derivate (≥50%) of chitin, to which antimicrobial properties have been assigned. As bacterial resistances to antibiotics are increasing, alternative treatments have b...
Read MoreSuccessful Treatment of Perniosis With Hydroxychloroquine
Background: The current medical therapies for perniosis are diverse. The agents used have produced variable results and lack evidence-based data. Objective: To determine outcomes of patients with per...
Read MoreMedical and Surgical Management of Keloids: A Review
Keloids and hypertrophic scars are abnormal responses to wound healing. In general, keloids may exhibit proliferative growth beyond the margins of the scar and will remain persistent; whereas hypertr...
Read MoreAn Evidence-based Review of the Efficacy of Coal Tar Preparations in the Treatment of Psoriasis and Atopic Dermatitis
Background: There is a long history of using topical coal tar for the treatment of psoriasis and atopic dermatitis (AD). Objective: To review the literature on coal tar and its derivatives, without t...
Read MoreA Modified Scalpel in Hair Restoration
One limiting factor of hair transplantation is the amount of hair available in the patient donor scalp. Several techniques have been proposed as steel punches, multiblade knives, FUE (follicular unit...
Read MoreThe Use of the Flexible Scalpel for MinimallyInvasive and Minimally Scarring Surgery: A CaseSeries of Four Patients With Large Scalp Tumors
Reconstruction of the scalp after Mohs surgery can pose dilemmas for the dermatologic surgeon, especially for extensive tumors. The authors present a unique technique for removing large in-situ epide...
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Case Reports
A Rare Case of Non-Hodgkins B-cell Lymphoma in a Psoriatic Patient: A Case Report and Literature Review
Cyclosporine has been shown to increase the risk of lymphoma when used in organ transplant patients; however, studies have failed to demonstrate an increased risk of lymphoma when used at lower derma...
Read MoreCutaneous Lupus Erthyematosus and Anti-TNF-α Therapy: A Case Report With Review of the Literature
Anti-tumor necrosis factor-α (TNF-α) immunotherapy is revolutionizing the treatment of immune disease, particularly Crohn’s disease, rheumatoid arthritis, psoriatic arthritis and pso...
Read MoreFluconazole-associated Stevens-Johnson Syndrome
Fluconazole uncommonly causes Stevens-Johnson syndrome. A young Indian man who developed this adverse effect after his second dose of fluconazole is described. The characteristics of previously report...
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