Issue Archive
October 2015 | Volume 14 | Issue 10
Editorials
Diagnostic and Therapeutic Considerations for Onychomycosis and Cutaneous Superficial Fungal Infections
Dermatophyte infections of the skin and nails are increasing, with up to 25% of the worldwide population affected; and they account for approximately 10% to 20% of all visits to the dermatology office...
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Original Articles
Anti-IL-23 Phase II Data for Psoriasis: A Review
BACKGROUND: Monoclonal antibodies that target both Interleukin (IL)-12 and IL-23 have shown great efficacy in the treatment of psoriasis. Recent evidence suggests that IL-23 serves a more critical rol...
Read MoreEvaluation of a Newly Available ELISA for Envoplakin Autoantibodies for the Diagnosis of Paraneoplastic Pemphigus
IMPORTANCE: Paraneoplastic pemphigus (PNP) is routinely diagnosed by the presence of autoantibodies for desmoplakin by indirect immunofluorescence (IIF) on rat bladder epithelium (RBE). IIF on RBE has...
Read MoreCrisaborole Topical Ointment, 2% in Adults With Atopic Dermatitis: A Phase 2a, Vehicle-Controlled, Proof-of-Concept Study
BACKGROUND: A novel approach for treating atopic dermatitis (AD) is the inhibition of phosphodiesterase 4 (PDE4), an enzyme involved in the proinflammatory cascade. Crisaborole topical ointment, 2% is...
Read MoreThe Power of Combination Topical Therapy for Psoriasis
Psoriasis is a chronic inflammatory skin disease where the use of topical corticosteroids is a mainstream treatment. However, the continuous use of high potency topical corticosteroids is limited by a...
Read MoreCurrent Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management
Seborrheic keratosis (SK) is among the most common cutaneous lesions, affecting some 83 million Americans. Biologically benign, SK lesions do not require removal for medical reasons unless histologic ...
Read MoreMohs Mapping in the Cloud: An Innovative Method for Mapping Tissue in Mohs Surgery
BACKGROUND: Mohs micrographic surgery (MMS) is the most useful surgical method for the treatment of skin cancer. One of the key factors in MMS is the mapping of the excised tissue in relation to its o...
Read MorePsoriasis Targeted Therapy: Characterization of Interleukin 17A Expression in Subtypes of Psoriasis
INTRODUCTION: Psoriasis is a chronic, inflammatory autoimmune disease that affects about 3% of the general population in the United States with 17% suffering from moderate to severe psoriasis. The dis...
Read MoreNaftifine Hydrochloride Gel 2%: An Effective Topical Treatment for Moccasin-Type Tinea Pedis
BACKGROUND: Naftifine hydrochloride (naftifine) is a topical antifungal of the allylamine class, displaying fungicidal and fungistatic activity. Naftifine is generally used to treat interdigital tinea...
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Features
Resident Rounds: Part 1 - Program Spotlight: University of Missouri Department of Dermatology
Resident Rounds is a section of the JDD dedicated to highlighting various dermatology departments with residency training programs. Resident Rounds includes 3 sections: (1) a program spotlight highlig...
Read MoreResident Rounds: Part II - Autosomal Dominant Disorders With Malignant Potential: Board Review
Time to Raise the Bar to Psoriasis Area Severity Index 90 and 100
Resident Rounds: Part III - Cutaneous Sarcoidosis in a Blepharoplasty Scar
A Case of Erythema Elevatum Diutinum With Pancytopenia: Focus on Dapsone-Induced Hematologic Side Effects and Colchicine as a Safe Treatment Option
Erythema elevatum diutinum (EED) is a disease characterized by red to yellow cutaneous papules, nodules, and plaques distributed mainly over extensor surfaces. Histologically, there is leukocytoclasti...
Read MoreClinical Trial Review
Clinical Trial Review is a JDD department designed to provide physicians with information on drugs and devices undergoing clinical testing. It is our goal to inform the reader of the status of select ...
Read MorePipeline Previews
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from the...
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Case Reports
Topical Human Epidermal Growth Factor in the Treatment of Senile Purpura and the Prevention of Dermatoporosis
BACKGROUND: Senile purpura presents itself as a largely unexplored challenge as it has been long thought of as a benign condition without long-term health sequelae. It is becoming increasingly accepte...
Read MorePsoriasiform Eruption Secondary to the Use of Adalimumab
Induced psoriasiform eruption, especially by anti-tumor necrosis factor alpha, was a rather rare event but nowadays cases are increasing because of its prescription for many different diseases. There ...
Read MoreTopical Treatment With Liposomal Sodium Copper Chlorophyllin Complex in Subjects With Facial Redness and Erythematotelangiectatic Rosacea: Case Studies
Physicians are often presented with patients complaining of facial redness and difficult to control rosacea. The water soluble sodium copper chlorophyllin complex has been shown to have anti-oxidant, ...
Read MoreSofosbuvir-Induced Erythrodermic Pityriasis Rubra Pilaris-Like Drug Eruption
Until 2011, the standard-of-care therapy for patients with hepatitis C consisted of interferon and ribavirin. The recent advent of new targeted therapies against this virus has provided more options o...
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Supplements
Improving Clinical Outcomes When Treating Dermatophyte Infections
Onychomycosis to Fungal Superinfection: Prevention Strategies and Considerations
Onychomycosis is the most common fungal skin infection, and it is frequently seen in the setting of other concomitant fungal infections, the most common being tinea pedis. Infected nails become a rese...
Read MoreNew Topical Therapeutic Options in the Management of Superficial Fungal Infections
Dermatophyte infections of the skin and nails are common in the United States. These infections warrant treatment because they are symptomatic and progressive, and can predispose patients to superinfe...
Read MoreIdentifying Signs of Tinea Pedis: A Key to Understanding Clinical Variables
Tinea pedis is a frequently encountered dermatophytosis affecting the superficial skin of the feet, primarily of adults. The prevalence of tinea pedis has increased over the last several decades due t...
Read MoreAssessment of Dermatophytosis Treatment Studies: Interpreting the Data
Antifungal therapy has recently enjoyed a resurgence of interest due to the introduction of a number of new formulations of topical drugs and novel molecules. This has led to a plethora of new publica...
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