Issue Archive
June 2014 | Volume 13 | Issue 6
Editorials
Hot Topics in Acne
Acne: Novel Findings and Treatment Paradigms
Acne is perhaps the most prevalent skin disease in Western societies, yet dermatologists are now learning that simply "dubbing the medicine on ...
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Original Articles
Systematic Review of Vismodegib Toxicity Profile in the Treatment of Advanced Basal Cell Carcinomas Compared to Other Systemic Therapies in Dermatology
Vismodegib is a first-in-class, hedgehog-signal inhibitor that is FDA-approved for use with advanced basal cell carcinomas (BCCs) that cannot be removed by either surgical resection or treated with ra...
Read MoreIncorrect Reconstitution of IncobotulinumtoxinA Leads to Loss of Neurotoxin
BACKGROUND: IncobotulinumtoxinA (INCO) was approved for aesthetic use in the United States in 2011. When reconstituted per manufacturer’s instructions, diminished delivery of INCO in US may res...
Read MoreEfficacy and Safety of Ingenol Mebutate 0.015% Gel After Cryosurgery of Actinic Keratosis: 12-Month Results
INTRODUCTION: Recurrence rates of actinic keratosis (AK) lesions after cryosurgery are high, and this treatment does not address field cancerization. We investigated the efficacy and safety of field t...
Read MoreThe Duration of Acne Treatment
BACKGROUND: Acne has a ~90% lifetime prevalence, however the duration of the condition and its treatment is not well characterized. The purpose of this study was to estimate for how long acne patients...
Read MoreTolerability of Topical Antimicrobials in Treatment of Acne Vulgaris
BACKGROUND: Thirty to 40% of patients using topical treatments do not comply with their treatment regimen.
OBJECTIVE: To examine how tolerability is assessed, tolerability ratings, and clinical...
Read MoreResults of a Phase III, Double-Blind, Randomized, Parallel-Group, Non-Inferiority Study Evaluating the Safety and Efficacy of Isotretinoin-Lidose in Patients With Severe Recalcitrant Nodular Acne
BACKGROUND: Isotretinoin-Lidose, the first new formulation of isotretinoin in 30 years, differs from previously approved isotretinoin formulations in that it is less dependent on the presence of fat i...
Read MoreSafety and Efficacy Comparison of Minocycline Microgranules vs Lymecycline in the Treatment of Mild to Moderate Acne: Randomized, Evaluator-blinded, Parallel, and Prospective Clinical Trial for 8 Weeks
BACKGROUND: Minocycline and lymecycline are used in the treatment of acne, but there is not enough evidence to support superior efficacy of one of them.
METHODS: 170 participants from 14 to 34 ...
Read MoreRapid Treatment of Mild Acne With a Novel Skin Care System Containing 1% Salicylic Acid, 10% Buffered Glycolic Acid, and Botanical Ingredients
The biggest hurdle in the treatment of acne vulgaris is patient non-compliance that is due in large part to poor tolerability to common acne medications. As such, new acne treatments must be developed...
Read MoreRandomized, Phase 2, Dose-Ranging Study in the Treatment of Rosacea With Encapsulated Benzoyl Peroxide Gel
OBJECTIVE: Compare the safety and efficacy of 1% and 5% silica encapsulated benzoyl peroxide (E-BPO) in patients with papulopustular rosacea.
DESIGN: Multi-centered randomized, double blind, vehi...
Read MoreThe Quality of Life Impact of Acne and Rosacea Compared to Other Major Medical Conditions
BACKGROUND: Acne and rosacea cause significant negative impact on quality of life. There is limited information comparing the health-related quality of life (HRQL) impact associated with acne and rosa...
Read MoreImprovement in Facial Erythema Within 30 Minutes of Initial Application of Brimonidine Tartrate in Patients With Rosacea
BACKGROUND: Brimonidine tartrate (BT) 0.5% gel demonstrated significantly greater efficacy versus vehicle gel once-daily for the treatment of moderate to severe erythema of rosacea.
OBJECTIVES: T...
Read MoreCutaneous Tolerability to Tretinoin Shows Little Variation With Fitzpatrick Skin Type
Determinants of skin irritability are poorly understood. This study aims to assess differences in cutaneous safety/irritation based on Fitzpatrick skin type among patients with acne treated with treti...
Read MoreA Retrospective Analysis of 72 Patients on Prior Efalizumab Subsequent to the Time of Voluntary Market Withdrawal in 2009
BACKGROUND: Efalizumab was voluntarily withdrawn from the market in April 2009 after four cases of Progressive Multifocal Leukoencephalopathy.
OBJECTIVE: To review the baseline characteristics ...
Read MoreOnly Skin Deep: Optimism and Public Self-Consciousness Did Not Associate With the Placebo Response in a Dermatology Clinical Trial
OBJECTIVE: Although not well-understood, dermatologic diseases studied in clinical trials often demonstrate substantial response to placebo. The study objective is to determine if optimism, public sel...
Read MoreThe Effect of Desonide Hydrogel on Pruritus Associated With Atopic Dermatitis
Itch is a common and troubling symptom of atopic dermatitis. It is not mediated by histamine, and standard anti-itch therapies, therefore, have limited benefit for most AD patients. Instead, anti-...
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Features
The Changing Face of Challenges in the Management of Acne and Rosacea
Therapeutic Update on Acne Scarring
Resident Rounds Part I. Program Spotlight: University of Oklahoma Dermatology Residency Program
Resident Rounds is a section of the JDD dedicated to highlighting various dermatology departments with residency training programs. Resident Rounds includes three sections: (1) a program spotlight hi...
Read MoreResident Rounds Part II: Anesthetics Review
Resident Rounds Part III: Plaque on Left Areola of an African-American Woman
Basal cell carcinoma (BCC) is the most common cutaneous malignancy, and usually presents on sun-exposed areas of the skin. Unsurprisingly, BCC appearing on the nipple-areola complex (NAC) is rare, an...
Read MorePipeline Previews
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from th...
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Case Reports
Successful Desensitization to Brentuximab Vedotin After Hypersensitivity Reaction
Monoclonal antibodies (mAb) have become the standard of care for numerous diseases. However, side effects including infusion and hypersensitivity reactions experienced by patients continue to be a...
Read MoreLeuprolide Acetate-Induced Generalized Papular Eruption
Leuprolide acetate, a gonadotropin-releasing hormone agonist, is used in the treatment of prostate cancer. We report a unique case of a disseminated papular rash following leuprolide acetate injection...
Read MoreRosacea Fulminans With Extrafacial Lesions in an Elderly Man: Successful Treatment With Subantimicrobial-Dose Doxycycline
Rosacea fulminans, previously known as pyoderma faciale, is a rare disease occurring almost exclusively in young women characterized by the sudden eruption of coalescing papules and pustules, a...
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Supplements
Evolving Concepts in the Pathogenesis of Acne Vulgaris
Re-evaluating Treatment Targets in Acne Vulgaris: Adapting to a New Understanding of Pathophysiology
Two primary factors are changing current approaches to the management of acne vulgaris (AV): the continuously evolving role of Propionibacterium acnes in the pathophysiology of AV and recent evidence ...
Read MoreAcne Vulgaris in Skin of Color: Understanding Nuances and Optimizing Treatment Outcomes
According to the United States national survey data, acne vulgaris is the leading dermatologic diagnosis among African Americans, Hispanics/Latinos, and Asians/Pacific Islanders. This patient populati...
Read MoreAntibiotic Resistance and Acne: Where We Stand and What the Future Holds
Antibiotic resistance is described as “a global public health challenge” and a “major health security challenge of the 21st century” by global health authorities,1 and there is...
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